Villarreal will host Lech Poznan at the Estadio de la Cerámica in the first game of their Europa Conference League campaign at 6.45pm local time.
They will be making their first appearance in the competition as favourites after reaching the Champions League semi-finals last season.
Unai Emery is expected to rotate his squad from the team that beat Elche 4-0 on Sunday. He is hoping to rest some of his key players before their important match against Real Betis this coming weekend.
The fixture could see Johan Mojica make his debut for The Yellow Submarine following his arrival from Elche this summer. Pepe Reina will most likely be rested due to a hip discomfort.
Marca predict that Emery will start the following XI against Lech Poznan: Gerómino Rulli – Adrián de la Fuente, Aïssa Mandi, Jorge Cuenca, Johan Mojica – Samuel Chukwueze, Manu Morlanes, Francis Coquelin, Álex Baena – José Luis Morales, Nicolas Jackson.